TY - JOUR
T1 - Foodborne ESKAPE Biofilms and Antimicrobial Resistance
T2 - lessons Learned from Clinical Isolates
AU - Patil, Amrita
AU - Banerji, Rajashri
AU - Kanojiya, Poonam
AU - Saroj, Sunil D.
N1 - Funding Information:
The work was supported by the Ramalingaswami fellowship program of Department of Biotechnology, India under grant BT/RLF/Re-entry/41/2015; Major research project grant of Symbiosis International (Deemed University) under grant SIU/SCRI/MJRP-Approval/2019/1556; ERASMUS+ under grant 598515-EPP-1-2018-1-IN-EPPKA2-CBHE-JPDepartment of Biotechnology, Ministry of Science and Technology [BT/RLF/Re-entry/41/2015]; Major research project grant of Symbiosis International (Deemed University) [SIU/SCRI/MJRP-Approval/2019/1556]. AP is supported by the ERASMUS+ grant. RB and PK are supported by the junior research fellowship program of the Symbiosis International (Deemed University).
Funding Information:
AP is supported by the ERASMUS+ grant. RB and PK are supported by the junior research fellowship program of the Symbiosis International (Deemed University).
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - The ESKAPE pathogens (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are identified to be multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR); thereby, imposing severe challenges in the treatment of associated infections. ESKAPE pathogens colonize on various biotic and abiotic surfaces; biofilms formed by these pathogens are a potential source for food contamination. Moreover, biofilms play a pivotal role in the development of antimicrobial-resistant (AMR) strains. Hence, the frequent isolation of antimicrobial-resistant ESKAPE pathogens from food products across the globe imposes a threat to public health. A comprehensive understanding of the adhesion signaling involved in the polymicrobial and single-species biofilm will assist in developing alternative preservation techniques and novel therapeutic strategies to combat ESKAPE pathogens. The review provides a comprehensive overview of the signaling mechanisms that prevail in the ESKAPE pathogens for adhesion to abiotic and biotic surfaces and molecular mechanisms associated with poly-microbial biofilm-assisted AMR in ESKAPE.
AB - The ESKAPE pathogens (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are identified to be multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR); thereby, imposing severe challenges in the treatment of associated infections. ESKAPE pathogens colonize on various biotic and abiotic surfaces; biofilms formed by these pathogens are a potential source for food contamination. Moreover, biofilms play a pivotal role in the development of antimicrobial-resistant (AMR) strains. Hence, the frequent isolation of antimicrobial-resistant ESKAPE pathogens from food products across the globe imposes a threat to public health. A comprehensive understanding of the adhesion signaling involved in the polymicrobial and single-species biofilm will assist in developing alternative preservation techniques and novel therapeutic strategies to combat ESKAPE pathogens. The review provides a comprehensive overview of the signaling mechanisms that prevail in the ESKAPE pathogens for adhesion to abiotic and biotic surfaces and molecular mechanisms associated with poly-microbial biofilm-assisted AMR in ESKAPE.
KW - ESKAPE
KW - antimicrobial resistance
KW - biofilms
KW - polymicrobial
KW - signaling
UR - http://www.scopus.com/inward/record.url?scp=85104489802&partnerID=8YFLogxK
U2 - 10.1080/20477724.2021.1916158
DO - 10.1080/20477724.2021.1916158
M3 - Article
C2 - 33851566
AN - SCOPUS:85104489802
SN - 2047-7724
VL - 115
SP - 339
EP - 356
JO - Pathogens and Global Health
JF - Pathogens and Global Health
IS - 6
ER -
