Formation of Electrically Active Clusterized Neural Networks

Ronen Segev, Morris Benveniste, Yoash Shapira, Eshel Ben-Jacob

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Ordinarily, in vitro neurons self-organize into homogeneous networks of single neurons linked by dendrites and axons. We show that under special conditions they can also self-organize into neuronal clusters, which are linked by bundles of axons. Multielectrode array measurement reveals that the clusterized networks are also electrically active and exhibit synchronized bursting events similar to those observed in the homogeneous networks. From time-lapse recording, we deduced the features required for the neuronal clusterized versus homogeneous self-organization and developed a simple model for testing their validity.

Original languageEnglish
Pages (from-to)4
Number of pages1
JournalPhysical Review Letters
Issue number16
StatePublished - 1 Jan 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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