Formulation and characterization of blended cinnamon oil-usnicacid nanoemulsion for topical application

Peeyush Kumar, P. W. Ramteke, Avinash C. Pandey, Himanshu Pandey

Research output: Contribution to journalArticlepeer-review


The objective of the present study was to prepare and characterize thermodynamically stable blended cinnamon oil and usnic acid nanoemulsion (CUN). CUN was prepared using titration method by selecting different components (oil, surfactant and co-surfactant) on the basis of solubility and emulsification ability. The drug-loaded nanoemulsions (NEs) were successfully prepared, which contained 6% cinnamon essential oil, 0.5% usnic acid as drug, 24% Tween 80 as surfactant, 12% ethanol as co-surfactant and 57.5% deionized water and further characterized. The prepared formulation exhibited an optical transparency of 99.66%, globule size of 108.61 ± 1.52 nm, and polydispersity index of 0.139 ± 0.029. All formulations were stable for 6 months. It can be concluded from the study that cinnamom oil and usnic acid nanoemulsion was compatible and stable at room temperature.

Original languageEnglish
Pages (from-to)2512-2518
Number of pages7
JournalLatin American Journal of Pharmacy
Issue number12
StatePublished - 1 Jan 2018
Externally publishedYes


  • Cinnamon oil
  • Nanoemulsion
  • Nanotechnology
  • Phase diagram
  • Usnic acid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery


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