TY - JOUR
T1 - Four component Ugi reaction based small-molecule probes for integrated phenotypic screening
AU - Thangaraj, Manikandan
AU - Lialin, Ksenia
AU - Dandela, Rambabu
AU - Adepu, Raju
AU - David, Shimrit
AU - Mizrachi, Meital Shema
AU - Meijler, Michael M.
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).
AB - Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).
KW - Multicomponent reactions (MCRs)
KW - P. aeruginosa
KW - Quorum sensing
UR - http://www.scopus.com/inward/record.url?scp=85187984239&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2024.107257
DO - 10.1016/j.bioorg.2024.107257
M3 - Article
C2 - 38493639
AN - SCOPUS:85187984239
SN - 0045-2068
VL - 146
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
M1 - 107257
ER -