Four Streams Within the Prefrontal Cortex: Integrating Structural and Functional Connectivity

Dorit Ben Shalom, Georgios P. Skandalakis

Research output: Contribution to journalArticlepeer-review

Abstract

Merging functional evidence derived from studies of autism spectrum disorder and attention-deficit/hyperactivity disorder converges in four neural streams of the prefrontal cortex, hence suggesting a model of information processing through four streams: motor through Brodmann area (BA) 8, emotion through BA 9, memory through BA 10, and emotional-related sensory through BA 11. A growing body of functional data has been supporting this model of information processing. Nevertheless, the underlying structural connectivity was only recently unveiled by a population-based high-definition tractography study with data from 1,065 individuals. This update provides a brief overview of recent evidence supporting the anatomofunctional integration of the four streams of the prefrontal cortex and reviews the white matter fiber tracts subserving the four streams.

Original languageEnglish
JournalNeuroscientist
DOIs
StateAccepted/In press - 1 Jan 2024

Keywords

  • BA 10
  • BA 11
  • BA 8
  • BA 9
  • emotion
  • memory
  • motor
  • prefrontal
  • sensory

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology

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