Fragmentation of laser-desorbed 9-substituted adenines

E. Nir, M. S. De Vries

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In laser desorption of a series of cyclically 9-substituted adenines, followed by multiphoton ionization, we observed characteristic fragmentation. This is in marked contrast to laser desorption under identical conditions of cyclically 9-substituted guanines, for which we obtained predominantly the parent mass. By applying resonant 2 photon ionization spectroscopy (R2PI) to the laser-desorbed, jet-cooled fragments, we show that the fragmentation is induced by the desorption process and not by the excitation/ionization process. Fragmentation takes place between C′2 and C′3 and between C′1 and O6 in the sugar ring. By adding a propyl bridge between C′2 and C′3, the fragmentation pathway changes to a cleavage of the C′4-C′5 bond in the sugar ring. This allowed us to record R2PI spectra of a fragment species that can serve as a model for adenosine.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Mass Spectrometry
Volume219
Issue number1
DOIs
StatePublished - 1 Aug 2002
Externally publishedYes

Keywords

  • Adenines
  • DNA bases
  • Fragmentation
  • Jet-cooling
  • Laser desorption
  • R2PI spectrum

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry

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