Freeze the dynamicity: Charge transfer complexation assisted control over the reaction pathway

Nilotpal Singha, Basab Kanti Das, Bapan Pramanik, Saurav Das, Debapratim Das

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Charge transfer (CT) complexes between electron donor and acceptor molecules provide unique alternate D-A arrangements. However, these arrangements cannot be fully translated into chemo-selective organic transformations as the dynamicity of CT complexes in solution results in the co-existence of D-A assemblies and free monomers during the reaction time-scale. A conceptually new strategy to exploit CT complexes toward chemo-selective products by means of seizing the dynamicity of CT complexes is reported here. Aqueous CT complexes of donor and acceptor molecules bearing reactive thiol groups were frozen instantly and cryo-desiccated to get the alternate D-A assemblies intact in the solid state. Oxidation of reactive thiols in an oxygen rich solvent in the solid state resulted in the formation of the hetero-dimer exclusively. CT complexation and appropriate molecular arrangements are the key factors behind successful execution of this novel methodology. The strategy also paves the way to prepare unsymmetrical disulfide molecules from two dissimilar thiols.

Original languageEnglish
Pages (from-to)10035-10039
Number of pages5
JournalChemical Science
Issue number43
StatePublished - 1 Jan 2019
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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