TY - JOUR
T1 - Frequency and prognostic significance of secondary ventricular fibrillation complicating acute myocardial infarction
AU - Behar, Solomon
AU - Reicher-Reiss, Henrietta
AU - Shechter, Michael
AU - Rabinowitz, Babeth
AU - Kaplinsky, Elieser
AU - Abinader, Edward
AU - Agmon, Jacob
AU - Friedman, Yaacov
AU - Barzilai, Jacob
AU - Kauli, Nissim
AU - Kishon, Yehezkiel
AU - Palant, Abraham
AU - Peled, Benyamin
AU - Reisin, Leonardo
AU - Schlesinger, Zwi
AU - Zahavi, Izhar
AU - Zion, Monty
AU - Goldbourt, Uri
PY - 1993/1/15
Y1 - 1993/1/15
N2 - The incidence of secondary ventricular fibrillation (VF) complicating acute myocardial infarction (AMI) was 2.4% in a large cohort of unselected patients with AMI (142 of 5,839). Secondary VF was more frequent in patients with recurrent AMI (4%) than in those with a first AMI (1.9%) (p < 0.01). The hospital course was more complicated and in-hospital mortality was significantly higher in patients with secondary VF than in those with the same clinical hemodynamic condition but without VF (56 vs 16%; p < 0.0001). Multivariate analyses confirmed secondary VF complicating AMI as an independent predictor of high in-hospital mortality, with an odds ratio of 7 (95% confidence interval 4.6-10.6). However, long-term mortality after discharge (mean follow-up 5.5 years) was not increased in patients with as compared with those without secondary VF (39 vs 42%). These findings were also true when patients receiving β blockers and antiarrhythmic therapy were excluded from analysis. Thus, this life-threatening arrhythmia occurring during hospitalization is not a marker of recurrent susceptibility to VF or an indicator of increased mortality after discharge from the hospital.
AB - The incidence of secondary ventricular fibrillation (VF) complicating acute myocardial infarction (AMI) was 2.4% in a large cohort of unselected patients with AMI (142 of 5,839). Secondary VF was more frequent in patients with recurrent AMI (4%) than in those with a first AMI (1.9%) (p < 0.01). The hospital course was more complicated and in-hospital mortality was significantly higher in patients with secondary VF than in those with the same clinical hemodynamic condition but without VF (56 vs 16%; p < 0.0001). Multivariate analyses confirmed secondary VF complicating AMI as an independent predictor of high in-hospital mortality, with an odds ratio of 7 (95% confidence interval 4.6-10.6). However, long-term mortality after discharge (mean follow-up 5.5 years) was not increased in patients with as compared with those without secondary VF (39 vs 42%). These findings were also true when patients receiving β blockers and antiarrhythmic therapy were excluded from analysis. Thus, this life-threatening arrhythmia occurring during hospitalization is not a marker of recurrent susceptibility to VF or an indicator of increased mortality after discharge from the hospital.
UR - http://www.scopus.com/inward/record.url?scp=0027446399&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(93)90730-Z
DO - 10.1016/0002-9149(93)90730-Z
M3 - Article
AN - SCOPUS:0027446399
SN - 0002-9149
VL - 71
SP - 152
EP - 156
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 2
ER -