Frequency domain analysis of nonlinear glucose simulation models

Amjad Abu-Rmileh, Johan Schoukens

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Simulation models are frequently used in the development of the artificial pancreas for patients with diabetes. In this paper, frequency domain measurement techniques are used to perform a comparative analysis of widely used nonlinear simulation models of the glucose regulation system in type 1 diabetes. The analysis highlights the main differences between the models under study, based on a nonparametric estimate of their frequency response functions. The underlying linear dynamics, the nature and level of model nonlinearity, and the effect of nonlinear behavior on linear modeling are used as comparison criteria. The analysis shows that, a better understanding of the behavior of such nonlinear systems and the limitations of their linear approximates provides the means to a more careful use in simulations and control design.

Original languageEnglish
Title of host publicationProceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
PublisherIFAC Secretariat
Number of pages6
ISBN (Print)9783902823106
StatePublished - 1 Jan 2012
Externally publishedYes
Event8th IFAC Symposium on Biological and Medical Systems, BMS 2012 - Budapest, Hungary
Duration: 29 Aug 201231 Aug 2012

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
ISSN (Print)1474-6670


Conference8th IFAC Symposium on Biological and Medical Systems, BMS 2012


  • Artificial pancreas
  • Best linear approximation
  • Frequency domain
  • Nonlinear distortion
  • Type 1 diabetes

ASJC Scopus subject areas

  • Control and Systems Engineering


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