Frequency domain analysis of nonlinear glucose simulation models

Amjad Abu-Rmileh; Johan Schoukens

doi:10.3182/20120829-3-HU-2029.00041

Frequency domain analysis of nonlinear glucose simulation models

Amjad Abu-Rmileh
, Johan Schoukens

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Simulation models are frequently used in the development of the artificial pancreas for patients with diabetes. In this paper, frequency domain measurement techniques are used to perform a comparative analysis of widely used nonlinear simulation models of the glucose regulation system in type 1 diabetes. The analysis highlights the main differences between the models under study, based on a nonparametric estimate of their frequency response functions. The underlying linear dynamics, the nature and level of model nonlinearity, and the effect of nonlinear behavior on linear modeling are used as comparison criteria. The analysis shows that, a better understanding of the behavior of such nonlinear systems and the limitations of their linear approximates provides the means to a more careful use in simulations and control design.

Original language	English
Title of host publication	Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
Publisher	IFAC Secretariat
Pages	28-33
Number of pages	6
Edition	18
ISBN (Print)	9783902823106
DOIs	https://doi.org/10.3182/20120829-3-HU-2029.00041
State	Published - 1 Jan 2012
Externally published	Yes
Event	8th IFAC Symposium on Biological and Medical Systems, BMS 2012 - Budapest, Hungary Duration: 29 Aug 2012 → 31 Aug 2012

Publication series

Name	IFAC Proceedings Volumes (IFAC-PapersOnline)
Number	18
Volume	45
ISSN (Print)	1474-6670

Conference

Conference	8th IFAC Symposium on Biological and Medical Systems, BMS 2012
Country/Territory	Hungary
City	Budapest
Period	29/08/12 → 31/08/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Artificial pancreas
Best linear approximation
Frequency domain
Nonlinear distortion
Type 1 diabetes

ASJC Scopus subject areas

Control and Systems Engineering

Access to Document

10.3182/20120829-3-HU-2029.00041

Cite this

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title = "Frequency domain analysis of nonlinear glucose simulation models",

abstract = "Simulation models are frequently used in the development of the artificial pancreas for patients with diabetes. In this paper, frequency domain measurement techniques are used to perform a comparative analysis of widely used nonlinear simulation models of the glucose regulation system in type 1 diabetes. The analysis highlights the main differences between the models under study, based on a nonparametric estimate of their frequency response functions. The underlying linear dynamics, the nature and level of model nonlinearity, and the effect of nonlinear behavior on linear modeling are used as comparison criteria. The analysis shows that, a better understanding of the behavior of such nonlinear systems and the limitations of their linear approximates provides the means to a more careful use in simulations and control design.",

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Abu-Rmileh, A & Schoukens, J 2012, Frequency domain analysis of nonlinear glucose simulation models. in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012. 18 edn, IFAC Proceedings Volumes (IFAC-PapersOnline), no. 18, vol. 45, IFAC Secretariat, pp. 28-33, 8th IFAC Symposium on Biological and Medical Systems, BMS 2012, Budapest, Hungary, 29/08/12. https://doi.org/10.3182/20120829-3-HU-2029.00041

Frequency domain analysis of nonlinear glucose simulation models. / Abu-Rmileh, Amjad; Schoukens, Johan.
Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012. 18. ed. IFAC Secretariat, 2012. p. 28-33 (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 45, No. 18).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Simulation models are frequently used in the development of the artificial pancreas for patients with diabetes. In this paper, frequency domain measurement techniques are used to perform a comparative analysis of widely used nonlinear simulation models of the glucose regulation system in type 1 diabetes. The analysis highlights the main differences between the models under study, based on a nonparametric estimate of their frequency response functions. The underlying linear dynamics, the nature and level of model nonlinearity, and the effect of nonlinear behavior on linear modeling are used as comparison criteria. The analysis shows that, a better understanding of the behavior of such nonlinear systems and the limitations of their linear approximates provides the means to a more careful use in simulations and control design.

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KW - Frequency domain

KW - Nonlinear distortion

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Frequency domain analysis of nonlinear glucose simulation models

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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