TY - JOUR
T1 - From disease-oriented to aging/longevity-oriented studies
AU - Budovsky, Arie
AU - Muradian, Khachik K.
AU - Fraifeld, Vadim E.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegeneration, diabetes type II, osteoporosis, and sarcopenia. Although an apparent paradox, it appears that the most effective way to delay or even to avert age-related diseases is to live longer. Common changes in the epigenetic control of gene expression may be one of the central mechanisms behind both aging and age-associated pathologies. If so, epigenetic interventions may serve in a twofold manner: (a) to extend the lifespan and (b) cure age-related degenerative diseases. Currently predominant disease-oriented paradigm should be reconsidered toward aging/longevity oriented.
AB - Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegeneration, diabetes type II, osteoporosis, and sarcopenia. Although an apparent paradox, it appears that the most effective way to delay or even to avert age-related diseases is to live longer. Common changes in the epigenetic control of gene expression may be one of the central mechanisms behind both aging and age-associated pathologies. If so, epigenetic interventions may serve in a twofold manner: (a) to extend the lifespan and (b) cure age-related degenerative diseases. Currently predominant disease-oriented paradigm should be reconsidered toward aging/longevity oriented.
UR - http://www.scopus.com/inward/record.url?scp=33744954695&partnerID=8YFLogxK
U2 - 10.1089/rej.2006.9.207
DO - 10.1089/rej.2006.9.207
M3 - Article
AN - SCOPUS:33744954695
VL - 9
SP - 207
EP - 210
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -
