From disease-oriented to aging/longevity-oriented studies

Arie Budovsky, Khachik K. Muradian, Vadim E. Fraifeld

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegeneration, diabetes type II, osteoporosis, and sarcopenia. Although an apparent paradox, it appears that the most effective way to delay or even to avert age-related diseases is to live longer. Common changes in the epigenetic control of gene expression may be one of the central mechanisms behind both aging and age-associated pathologies. If so, epigenetic interventions may serve in a twofold manner: (a) to extend the lifespan and (b) cure age-related degenerative diseases. Currently predominant disease-oriented paradigm should be reconsidered toward aging/longevity oriented.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalRejuvenation Research
Volume9
Issue number2
DOIs
StatePublished - 1 Jun 2006

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