From fat cell biology to public health preventive strategies - Pinpointing the critical period for obesity prevention

Michal Efrat, Sigal Tepper, Ruth Z. Birk

    Research output: Contribution to journalReview articlepeer-review

    8 Scopus citations

    Abstract

    The prevalence of childhood and adolescence obesity is increasing to alarming proportions worldwide and poses a major public health problem by significantly elevating the risks of chronic diseases. There is strong evidence that childhood overweight and obesity are risk factors for severe obesity over the whole life course. In fact, longitudinal studies have found that most overweight/ obese children would become overweight and obese adults. There is a lack of coupling in the scientific literature between adipose tissue development and bio logy to obesity prevention and treatment strategies. This is of utmost importance, especially regarding childhood and adolescence, as the major scientific paradigm in studies of adiposity is that the major number of adipocytes is set for life at this early age. This review discusses the current adipose cell biology paradigms to pinpoint the critical factors and periods in childhood overweight and obesity and, consecutively, to develop relevant prevention strategies.

    Original languageEnglish
    Pages (from-to)197-209
    Number of pages13
    JournalJournal of Pediatric Endocrinology and Metabolism
    Volume26
    Issue number3-4
    DOIs
    StatePublished - 1 Apr 2013

    Keywords

    • Adipocyte
    • Adolescents
    • Children
    • Hyperplastic obesity
    • Hypertrophic obesity
    • Obesity

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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