FTIR microscopic comparative study on normal, premalignant, and malignant tissues of human intenstine

Shaul Mordechai, Shmuel Argov, Ahmad O. Salman, Beny Cohen, Jagannathan Ramesh, Vitaly Erukhimovitch, Jed Goldstein, Igor Sinelnikov

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Fourier-Transform Infrared Spectroscopy (FTIR) employs a unique approach to optical diagnosis of tissue pathology based on the characteristic molecular vibrational spectra of the tissue. The architectural changes in the cellular and sub-cellular levels developing in abnormal tissue, including a majority of cancer forms, manifest themselves in different optical signatures, which can be detected in infrared spectroscopy. The biological systems we have studied include normal, premalignant (polyp) and malignant human colonic tissues from three patients. Our method is based on microscopic infrared study (FTIR-microscopy) of thin tissue specimens and a direct comparison with normal histopathological analysis, which serves as a 'gold' reference. The normal intestine tissue has a stronger absorption than polyp and cancerous types over a wide region in all three cases. The detailed analysis showed that there is a significant decrease in total phosphate and creatine contents for polyp and cancerous tissue types in comparison to the controls.

Original languageEnglish
Pages (from-to)231-242
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1 Dec 2000


  • Band fitting
  • Cancer diagnosis
  • Epithelial cells
  • FTIR microscopy
  • Intestinal cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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