FTIR spectroscopy examination of leukemia patients plasma

Vitaly Erukhimovitch; Marina Talyshinsky; Yelena Souprun; Mahmoud Huleihel

doi:10.1016/j.vibspec.2005.06.004

FTIR spectroscopy examination of leukemia patients plasma

Vitaly Erukhimovitch, Marina Talyshinsky, Yelena Souprun, Mahmoud Huleihel

Virology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm^-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	Vibrational Spectroscopy
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/j.vibspec.2005.06.004
State	Published - 16 Jan 2006

Keywords

Biomarkers
FTIR-microspectroscopy
Leukemia
Plasma

ASJC Scopus subject areas

Spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vibspec.2005.06.004

Cite this

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abstract = "In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.",

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T1 - FTIR spectroscopy examination of leukemia patients plasma

AU - Erukhimovitch, Vitaly

AU - Talyshinsky, Marina

AU - Souprun, Yelena

AU - Huleihel, Mahmoud

PY - 2006/1/16

Y1 - 2006/1/16

N2 - In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.

AB - In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.

KW - Biomarkers

KW - FTIR-microspectroscopy

KW - Leukemia

KW - Plasma

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FTIR spectroscopy examination of leukemia patients plasma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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