TY - JOUR
T1 - FTIR spectroscopy examination of leukemia patients plasma
AU - Erukhimovitch, Vitaly
AU - Talyshinsky, Marina
AU - Souprun, Yelena
AU - Huleihel, Mahmoud
PY - 2006/1/16
Y1 - 2006/1/16
N2 - In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.
AB - In the present study, Fourier-transform infrared microspectroscopy (micro-FTIR) was applied for the analysis of human plasma samples in order to detect spectral parameters, which might serve as biomarkers for monitoring and identification of leukemia patients. Samples of plasma were obtained from healthy and patient persons suffering from chronic lymphocytic leukemia and analyzed by micro-FTIR. The results show that spectral peaks at 1056, 1270 and 1592 cm-1 appearing in all examined samples obtained from healthy persons were significantly reduced in all tested patient samples. Cluster analysis of the obtained spectra at these specific regions provided excellent classification of the healthy and the patient samples which correlate completely with clinical data. These parameters could be used as a basis for developing a spectral method for the detection and identification of this type of human leukemia.
KW - Biomarkers
KW - FTIR-microspectroscopy
KW - Leukemia
KW - Plasma
UR - http://www.scopus.com/inward/record.url?scp=31744445825&partnerID=8YFLogxK
U2 - 10.1016/j.vibspec.2005.06.004
DO - 10.1016/j.vibspec.2005.06.004
M3 - Article
AN - SCOPUS:31744445825
SN - 0924-2031
VL - 40
SP - 40
EP - 46
JO - Vibrational Spectroscopy
JF - Vibrational Spectroscopy
IS - 1
ER -
