TY - JOUR
T1 - Functional Actin Networks under Construction
T2 - The Cooperative Action of Actin Nucleation and Elongation Factors
AU - Siton-Mendelson, Orit
AU - Bernheim-Groswasser, Anne
N1 - Funding Information:
We thank Tom Pollard and Nir Gov for careful reading of the manuscript and useful comments. A.B-G. thanks the Israel Science Foundation (grant #1618/15) for financial support.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Cells require actin nucleation factors to catalyze the formation of actin networks and elongation factors to control the rate and extent of actin polymerization. Earlier models suggested that the different factors assemble actin networks independently. However, recent evidence indicates that the assembly of most cellular networks involves multiple nucleation and elongation factors that work in concert. Here, we describe how these different factors cooperate, directly or indirectly, to promote the assembly of functional actin network in cells, both in the cytoplasm and nucleoplasm. We show that, in many cases, multiple factors collaborate to initiate network assembly and growth. The selection of specific sets of key players enables the cells to fine-tune network structure and dynamics, optimizing them for particular cellular functions.
AB - Cells require actin nucleation factors to catalyze the formation of actin networks and elongation factors to control the rate and extent of actin polymerization. Earlier models suggested that the different factors assemble actin networks independently. However, recent evidence indicates that the assembly of most cellular networks involves multiple nucleation and elongation factors that work in concert. Here, we describe how these different factors cooperate, directly or indirectly, to promote the assembly of functional actin network in cells, both in the cytoplasm and nucleoplasm. We show that, in many cases, multiple factors collaborate to initiate network assembly and growth. The selection of specific sets of key players enables the cells to fine-tune network structure and dynamics, optimizing them for particular cellular functions.
UR - http://www.scopus.com/inward/record.url?scp=85016435664&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2017.03.002
DO - 10.1016/j.tibs.2017.03.002
M3 - Review article
C2 - 28372857
AN - SCOPUS:85016435664
SN - 0376-5067
VL - 42
SP - 414
EP - 430
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 6
ER -