Functional architecture of the nuclear pore complex

Einat Grossman, Ohad Medalia, Monika Zwerger

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules. The NPC regulates nucleocytoplasmic transport of macromolecules, utilizing soluble receptors that identify and present cargo to the NPC, in a highly selective manner to maintain cellular functions. The NPC is composed of multiple copies of approximately 30 different proteins, termed nucleoporins, which assemble to form one of the largest multiprotein assemblies in the cell. In this review, we address structural and functional aspects of this fundamental cellular machinery.

Original languageEnglish
Pages (from-to)557-584
Number of pages28
JournalAnnual Review of Biophysics
Issue number1
StatePublished - 9 Jun 2012


  • Assembly
  • Cryo-electron tomography
  • Gene regulation
  • Nucleocytoplasmic transport
  • Nucleoporin
  • Structure

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Bioengineering
  • Biochemistry
  • Cell Biology


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