Functional aspects of ribosomal architecture: Symmetry, chirality and regulation

Raz Zarivach, Anat Bashan, Rita Berisio, Joerg Harms, Tamar Auerbach, Frank Schluenzen, Heike Bartels, David Baram, Erez Pyetan, Assa Sittner, Maya Amit, Harly A.S. Hansen, Maggie Kessler, Christa Liebe, Anja Wolff, Ilana Agmon, Ada Yonath

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The functional aspects of ribosomal architecture were studied. The ribosome possesses three tRNA binding sites named according to their function. It was observed that the small ribosomal subunit facilitates the initiation of the translation process and is involved in choosing the frame to be translated. The high-resolution structures of both ribosomal subunits revealed that most stages of protein biosynthesis including decoding of genetic information are navigated and controlled by the elaborate ribosomal architectural design.

Original languageEnglish
Pages (from-to)901-912
Number of pages12
JournalJournal of Physical Organic Chemistry
Volume17
Issue number11
DOIs
StatePublished - 1 Nov 2004
Externally publishedYes

Keywords

  • D-amino acids
  • Elongation arrest
  • Peptide-bond formation
  • Positional-catalysis
  • Protein CTC
  • Protein L22
  • Ribosomes
  • Tunnel dynamics

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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