Growth and maturation of B lymphocytes from stem cells require a series of complex processes that are dependent at least in part on growth factors. Uncontrolled expression of receptors from these early growth factors may contribute to a leukaemogenesis of such early B cell progenitors. We show here that early pre-pre-B cells, but not mature B cells, express the PDGF receptor-beta (PDGFR-β). These receptors contain a protein tyrosine kinase domain which is activated upon ligation with PDGF in pre-pre-B cells. Further, pre-pre-B leukaemia cells seem to express more PDGFR-β compared with their normal counterparts, suggesting a role for these receptors in growth promotion of leukaemia cells.
|Number of pages||8|
|Journal||Clinical and Experimental Immunology|
|State||Published - 1 Jan 1995|
- platelet-derived growth factor
- platelet-derived growth factor receptor-beta
ASJC Scopus subject areas
- Immunology and Allergy