Functional platelet-derived growth factor-beta (PDGF-β) receptor expressed on early B-lineage precursor cells

B. Trink, G. Wang, M. Shahar, N. Meydan, C. M. Roifman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Growth and maturation of B lymphocytes from stem cells require a series of complex processes that are dependent at least in part on growth factors. Uncontrolled expression of receptors from these early growth factors may contribute to a leukaemogenesis of such early B cell progenitors. We show here that early pre-pre-B cells, but not mature B cells, express the PDGF receptor-beta (PDGFR-β). These receptors contain a protein tyrosine kinase domain which is activated upon ligation with PDGF in pre-pre-B cells. Further, pre-pre-B leukaemia cells seem to express more PDGFR-β compared with their normal counterparts, suggesting a role for these receptors in growth promotion of leukaemia cells.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalClinical and Experimental Immunology
Volume102
Issue number2
DOIs
StatePublished - 1 Jan 1995
Externally publishedYes

Keywords

  • platelet-derived growth factor
  • platelet-derived growth factor receptor-beta

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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