TY - JOUR
T1 - Functionally distinct NMDA receptors mediate horizontal connectivity within Layer 4 of mouse barrel cortex
AU - Fleidervish, Ilya A.
AU - Binshtok, Alexander M.
AU - Gutnick, Michael J.
N1 - Funding Information:
This work was supported by a grant from the Israel Science Foundation, administered by the Israel Academy of Sciences, and by a grant from the French–Israeli Association for Scientific and Technological Research (AFIRST).
PY - 1998/1/1
Y1 - 1998/1/1
N2 - In sensory areas of neocortex, thalamocortical afferents project primarily onto the spiny stellate neurons of Layer 4. Anatomical evidence indicates that these cells receive most of their excitatory input from other cortical neurons, including other spiny stellate cells. Although this local network must play an important role in sensory processing, little is known about the properties of the neurons and synapses involved. We have produced a slice preparation of mouse barrel cortex that isolates Layer 4. We report that excitatory interaction between spiny stellate neurons is largely via N- methyl-D-aspartate receptors (NMDARs) and that a given neuron contains more than one type of NMDAR, as distinguished by voltage dependence. Thus, spiny stellate cells act as effective integrators of powerful and persistent NMDAR- mediated recurrent excitation.
AB - In sensory areas of neocortex, thalamocortical afferents project primarily onto the spiny stellate neurons of Layer 4. Anatomical evidence indicates that these cells receive most of their excitatory input from other cortical neurons, including other spiny stellate cells. Although this local network must play an important role in sensory processing, little is known about the properties of the neurons and synapses involved. We have produced a slice preparation of mouse barrel cortex that isolates Layer 4. We report that excitatory interaction between spiny stellate neurons is largely via N- methyl-D-aspartate receptors (NMDARs) and that a given neuron contains more than one type of NMDAR, as distinguished by voltage dependence. Thus, spiny stellate cells act as effective integrators of powerful and persistent NMDAR- mediated recurrent excitation.
UR - http://www.scopus.com/inward/record.url?scp=0032214481&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(00)80623-6
DO - 10.1016/S0896-6273(00)80623-6
M3 - Article
AN - SCOPUS:0032214481
SN - 0896-6273
VL - 21
SP - 1055
EP - 1065
JO - Neuron
JF - Neuron
IS - 5
ER -