TY - JOUR
T1 - Fundamental principles in bacterial physiology-history, recent progress, and the future with focus on cell size control
T2 - A review
AU - Jun, Suckjoon
AU - Si, Fangwei
AU - Pugatch, Rami
AU - Scott, Matthew
N1 - Funding Information:
For over a decade, we have been fortunate to have known some of the founders of bacterial physiology and those who were closely related to them, including Tove Atlung, Stuart Austin, Hans Bremer, Stephen Cooper, Willie Donachie, Pat Dennis, Flemming Hansen, Matt Meselson, Nanne Nanninga, the late Fred Neidhardt, the late Kurt Nordström, Steen Pedersen, Elio Schaechter, Conrad Woldringh, Andrew Wright, and Arieh Zaritsky. Many of them shared their inspirational anecdotes with us and taught us—with patience—their beautiful science that is largely forgotten. But above all, their stories, much of which we could not share in this article, reminded us what should drive scientists. We dedicate this article to them. We thank Serena Bradde, Johan Paulsson, Petra Levin, Massimo Vergassola, and the former and current members of Hwa and Jun labs for many years of collaborations and interactions, and Stephen Cooper, Willie Donachie, Petra Levin, JT Sauls, and Elio Schaechter for critical reading. RP would like to thank, Arnold Levine, Suzanne Christen, John Hopfield, Matteo Marsili and Antonio Celani for their long-lasting support and encouragment and for many helpful discussions. This work was supported by the Paul G Allen Frontiers Group, Pew Charitable Trust, NSF CAREER grant MCB-1253843, NIH grant R01 GM118565-01 (to SJ) and NSERC Discovery grant (to MS).
Publisher Copyright:
© 2018 IOP Publishing Ltd.
PY - 2018/2/28
Y1 - 2018/2/28
N2 - Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts. In the first part (sections 1-3), we review the first 'golden era' of bacterial physiology from the 1940s to early 1970s and provide a complete list of major references from that period. In the second part (sections 4-7), we explain how the pioneering work from the first golden era has influenced various rediscoveries of general quantitative principles and significant further development in modern bacterial physiology. Specifically, section 4 presents the history and current progress of the 'adder' principle of cell size homeostasis. Section 5 discusses the implications of coarse-graining the cellular protein composition, and how the coarse-grained proteome 'sectors' re-balance under different growth conditions. Section 6 focuses on physiological invariants, and explains how they are the key to understanding the coordination between growth and the cell cycle underlying cell size control in steady-state growth. Section 7 overviews how the temporal organization of all the internal processes enables balanced growth. In the final section 8, we conclude by discussing the remaining challenges for the future in the field.
AB - Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts. In the first part (sections 1-3), we review the first 'golden era' of bacterial physiology from the 1940s to early 1970s and provide a complete list of major references from that period. In the second part (sections 4-7), we explain how the pioneering work from the first golden era has influenced various rediscoveries of general quantitative principles and significant further development in modern bacterial physiology. Specifically, section 4 presents the history and current progress of the 'adder' principle of cell size homeostasis. Section 5 discusses the implications of coarse-graining the cellular protein composition, and how the coarse-grained proteome 'sectors' re-balance under different growth conditions. Section 6 focuses on physiological invariants, and explains how they are the key to understanding the coordination between growth and the cell cycle underlying cell size control in steady-state growth. Section 7 overviews how the temporal organization of all the internal processes enables balanced growth. In the final section 8, we conclude by discussing the remaining challenges for the future in the field.
KW - bacterial physiology
KW - cell size control
KW - quantitative biology
UR - http://www.scopus.com/inward/record.url?scp=85044220845&partnerID=8YFLogxK
U2 - 10.1088/1361-6633/aaa628
DO - 10.1088/1361-6633/aaa628
M3 - Review article
AN - SCOPUS:85044220845
SN - 0034-4885
VL - 81
JO - Reports on Progress in Physics
JF - Reports on Progress in Physics
IS - 5
M1 - 056601
ER -