Fungal Compounds in Down-Regulating Quorum Sensing

Barun Kumar; Dibyajit Lahiri; Soumya Pandit; Ankit Kumar; Kalpana Sharma; Prakriti Negi; Moupriya Nag

doi:10.1201/9781003300557-8

Fungal Compounds in Down-Regulating Quorum Sensing

Barun Kumar, Dibyajit Lahiri, Soumya Pandit, Ankit Kumar, Kalpana Sharma, Prakriti Negi, Moupriya Nag

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Fungi and bacteria allow communication when species live in large populations. Microorganisms-organisms generate proteins known as quorum-sensing molecules (QSMs), which manage their physical activities and enable cell-cell communications. QSMs generated by fungi include farnesol, tyrosol, phenyl ethanol, and tryptophol. Through therapeutics, better signal molecules limiting microbial pathogenicity rather than commensal bacteria are appealing for myriad factors, especially in light of the rise of treatment-resistant microbes. Quorum sensing disruption is an extensively researched topic because of its potential as an antibacterial-drug substitute. Various studies have been done to characterize the cytotoxic effect of natural and synthesized drugs on quorum signalling.

Original language	English
Title of host publication	Natural Products
Subtitle of host publication	Alternate Therapeutics as Quorum Sensing Inhibitors
Publisher	CRC Press
Pages	150-164
Number of pages	15
ISBN (Electronic)	9781003800477
ISBN (Print)	9781032292380
DOIs	https://doi.org/10.1201/9781003300557-8
State	Published - 1 Jan 2023
Externally published	Yes

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1201/9781003300557-8

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AU - Pandit, Soumya

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AU - Sharma, Kalpana

AU - Negi, Prakriti

AU - Nag, Moupriya

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AB - Fungi and bacteria allow communication when species live in large populations. Microorganisms-organisms generate proteins known as quorum-sensing molecules (QSMs), which manage their physical activities and enable cell-cell communications. QSMs generated by fungi include farnesol, tyrosol, phenyl ethanol, and tryptophol. Through therapeutics, better signal molecules limiting microbial pathogenicity rather than commensal bacteria are appealing for myriad factors, especially in light of the rise of treatment-resistant microbes. Quorum sensing disruption is an extensively researched topic because of its potential as an antibacterial-drug substitute. Various studies have been done to characterize the cytotoxic effect of natural and synthesized drugs on quorum signalling.

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Fungal Compounds in Down-Regulating Quorum Sensing

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