Future directions for monitoring treatment response in colorectal cancer

Avery S. Walker, Nathan P. Zwintscher, Eric K. Johnson, Justin A. Maykel, Alexander Stojadinovic, Aviram Nissan, Itzhak Avital, Björn L.D.M. Brücher, Scott R. Steele

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Treatment of advanced colon and rectal cancer has significantly evolved with the introduction of neoadjuvant chemoradiation therapy so much that, along with more effective chemotherapy regimens, surgery has been considered unnecessary among some institutions for select patients. The tumor response to these treatments has also improved and ultimately has been shown to have a direct effect on prognosis. Yet, the best way to monitor that response, whether clinically, radiologically, or with laboratory findings, remains controversial. The authors' aim is to briefly review the options available and, more importantly, examine emerging and future options to assist in monitoring treatment response in cases of locally advanced rectal cancer and metastatic colon cancer.

Original languageEnglish
Pages (from-to)44-57
Number of pages14
JournalJournal of Cancer
Volume5
Issue number1
DOIs
StatePublished - 12 Feb 2014
Externally publishedYes

Keywords

  • Biomarkers
  • Colorectal cancer
  • Imaging modalities
  • Response
  • Surgical timing
  • Watch and wait

ASJC Scopus subject areas

  • Oncology

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