Future prospect of nano-based drug delivery approaches against pancreatic cancer and expected pitfalls of the technology

K. R. Manu, Gurleen Kaur, Ananya Kar, Lopamudra Giri, Waleed H. Almalki, Neelima Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rambabu Dandela

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Several scientific breakthroughs have undergone radical change as a result of the development of nanotechnology, but the introduction of nanomedicine stands out. Research has focused particularly on nano-drug administration for the treatment of cancer. Phytochemicals, or naturally occurring plant molecules, have been widely studied for their anticancer qualities. Due to its effectiveness in diagnosing and treating different malignancies, nanotechnology has recently attracted more interest. Nanocarriers have been used to get beyond the drawbacks of traditional anticancer drug delivery methods, such as their nonspecificity, adverse side effects, burst release, and harm to healthy cells, and improved by nanocarriers. Numerous nanocarriers were developed, but still, only a little has gotten clinical clearance for the transfer of anticancer drugs to the precise areas in which they will exert their desired effects. In the following chapter, conventional therapy for pancreatic cancer, the prospects of nanotechnology in pancreatic cancer treatment, the varied types of the drug delivery system, and challenges of nano-based drug delivery systems for pancreatic cancer therapy applications are discussed, which promises in terms of possible clinical translation.

Original languageEnglish
Title of host publicationRecent Advances in Nanocarriers for Pancreatic Cancer Therapy
PublisherElsevier
Pages419-442
Number of pages24
ISBN (Electronic)9780443191428
ISBN (Print)9780443152887
DOIs
StatePublished - 1 Jan 2023
Externally publishedYes

Keywords

  • cancer
  • drug delivery systems
  • drug resistance
  • nanomedicine
  • Nanoparticles
  • pancreatic cancer treatment
  • therapeutic

ASJC Scopus subject areas

  • General Computer Science

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