GABA metabolism controls inhibition efficacy in the mammalian CNS

Hava Golan, Adolfo E. Talpalar, Drorit Schleifstein-Attias, Yoram Grossman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The effects of changes in γ-aminobutyric acid (GABA) metabolism on inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - 1 Jan 1996


  • Cytosolic γ-aminobutyric acid
  • Dentate gyrus
  • Glutamate decarboxylase block
  • Hippocampus
  • Paired pulse inhibition
  • Spinal monosynaptic reflex
  • Synaptic release
  • γ-Aminobutyric acid-T block

ASJC Scopus subject areas

  • Neuroscience (all)


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