GABA metabolism controls inhibition efficacy in the mammalian CNS

Hava Golan; Adolfo E. Talpalar; Drorit Schleifstein-Attias; Yoram Grossman

doi:10.1016/0304-3940(96)13061-5

GABA metabolism controls inhibition efficacy in the mammalian CNS

Hava Golan, Adolfo E. Talpalar, Drorit Schleifstein-Attias, Yoram Grossman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The effects of changes in γ-aminobutyric acid (GABA) metabolism on inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	217
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(96)13061-5
State	Published - 1 Jan 1996

Keywords

Cytosolic γ-aminobutyric acid
Dentate gyrus
Glutamate decarboxylase block
Hippocampus
Paired pulse inhibition
Spinal monosynaptic reflex
Synaptic release
γ-Aminobutyric acid-T block

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/0304-3940(96)13061-5

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title = "GABA metabolism controls inhibition efficacy in the mammalian CNS",

abstract = "The effects of changes in γ-aminobutyric acid (GABA) metabolism on inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).",

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AU - Golan, Hava

AU - Talpalar, Adolfo E.

AU - Schleifstein-Attias, Drorit

AU - Grossman, Yoram

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The effects of changes in γ-aminobutyric acid (GABA) metabolism on inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

AB - The effects of changes in γ-aminobutyric acid (GABA) metabolism on inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

KW - Cytosolic γ-aminobutyric acid

KW - Dentate gyrus

KW - Glutamate decarboxylase block

KW - Hippocampus

KW - Paired pulse inhibition

KW - Spinal monosynaptic reflex

KW - Synaptic release

KW - γ-Aminobutyric acid-T block

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GABA metabolism controls inhibition efficacy in the mammalian CNS

Abstract

Keywords

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