GABA withdrawal modifies network activity in cultured hippocampal neurons

H. Golan, K. Mikenberg, V. Greenberger, M. Segal

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Dissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout of GABA, the activity was no longer clustered in bursts and instead, the cells fired at a high rate tonic manner. The effect of removing GABA could be seen as long as 1 to 2 days after GABA withdrawal and is expressed as an increase in the number of active cells in a network, as well as in their firing rates. Such striking effects of GABA removal may underlie part of the GABA withdrawal syndrome seen elsewhere.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalNeural Plasticity
Issue number1-2
StatePublished - 1 Jan 2000


  • GABA withdrawal syndrome
  • Multi-electrode array

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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