GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

Ravinder Naik Dharavath; Celeste Pina-Leblanc; Victor M. Tang; Matthew E. Sloan; Yuliya S. Nikolova; Peter Pangarov; Anthony C. Ruocco; Kevin Shield; Daphne Voineskos; Daniel M. Blumberger; Isabelle Boileau; Nikki Bozinoff; Philip Gerretsen; Erica Vieira; Osnat C. Melamed; Etienne Sibille; Lena C. Quilty; Thomas D. Prevot

doi:10.3389/fncir.2023.1218737

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

Ravinder Naik Dharavath
, Celeste Pina-Leblanc
, Victor M. Tang
, Matthew E. Sloan
, Yuliya S. Nikolova
, Peter Pangarov
, Anthony C. Ruocco
, Kevin Shield
, Daphne Voineskos
, Daniel M. Blumberger
, Isabelle Boileau
, Nikki Bozinoff
, Philip Gerretsen
, Erica Vieira
, Osnat C. Melamed
, Etienne Sibille
, Lena C. Quilty
, Thomas D. Prevot

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.

Original language	English
Article number	1218737
Journal	Frontiers in Neural Circuits
Volume	17
DOIs	https://doi.org/10.3389/fncir.2023.1218737
State	Published - 1 Jan 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

GABA
alcohol use disorders
clinical trials
integrative approach
interventions
pharmacotherapy
translational
unmet need

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Sensory Systems
Cognitive Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.3389/fncir.2023.1218737

Cite this

Dharavath, R. N., Pina-Leblanc, C., Tang, V. M., Sloan, M. E., Nikolova, Y. S., Pangarov, P., Ruocco, A. C., Shield, K., Voineskos, D., Blumberger, D. M., Boileau, I., Bozinoff, N., Gerretsen, P., Vieira, E., Melamed, O. C., Sibille, E., Quilty, L. C., & Prevot, T. D. (2023). GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential. Frontiers in Neural Circuits, 17, Article 1218737. https://doi.org/10.3389/fncir.2023.1218737

@article{83a5e7b974184479a1c6a611b2aeafd6,

title = "GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential",

abstract = "Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1\% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.",

keywords = "GABA, alcohol use disorders, clinical trials, integrative approach, interventions, pharmacotherapy, translational, unmet need",

author = "Dharavath, \{Ravinder Naik\} and Celeste Pina-Leblanc and Tang, \{Victor M.\} and Sloan, \{Matthew E.\} and Nikolova, \{Yuliya S.\} and Peter Pangarov and Ruocco, \{Anthony C.\} and Kevin Shield and Daphne Voineskos and Blumberger, \{Daniel M.\} and Isabelle Boileau and Nikki Bozinoff and Philip Gerretsen and Erica Vieira and Melamed, \{Osnat C.\} and Etienne Sibille and Quilty, \{Lena C.\} and Prevot, \{Thomas D.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Dharavath, Pina-Leblanc, Tang, Sloan, Nikolova, Pangarov, Ruocco, Shield, Voineskos, Blumberger, Boileau, Bozinoff, Gerretsen, Vieira, Melamed, Sibille, Quilty and Prevot.",

year = "2023",

month = jan,

day = "1",

doi = "10.3389/fncir.2023.1218737",

language = "English",

volume = "17",

journal = "Frontiers in Neural Circuits",

issn = "1662-5110",

publisher = "Frontiers Media SA",

}

Dharavath, RN, Pina-Leblanc, C, Tang, VM, Sloan, ME, Nikolova, YS, Pangarov, P, Ruocco, AC, Shield, K, Voineskos, D, Blumberger, DM, Boileau, I, Bozinoff, N, Gerretsen, P, Vieira, E, Melamed, OC, Sibille, E, Quilty, LC & Prevot, TD 2023, 'GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential', Frontiers in Neural Circuits, vol. 17, 1218737. https://doi.org/10.3389/fncir.2023.1218737

TY - JOUR

T1 - GABAergic signaling in alcohol use disorder and withdrawal

T2 - pathological involvement and therapeutic potential

AU - Dharavath, Ravinder Naik

AU - Pina-Leblanc, Celeste

AU - Tang, Victor M.

AU - Sloan, Matthew E.

AU - Nikolova, Yuliya S.

AU - Pangarov, Peter

AU - Ruocco, Anthony C.

AU - Shield, Kevin

AU - Voineskos, Daphne

AU - Blumberger, Daniel M.

AU - Boileau, Isabelle

AU - Bozinoff, Nikki

AU - Gerretsen, Philip

AU - Vieira, Erica

AU - Melamed, Osnat C.

AU - Sibille, Etienne

AU - Quilty, Lena C.

AU - Prevot, Thomas D.

N1 - Publisher Copyright: Copyright © 2023 Dharavath, Pina-Leblanc, Tang, Sloan, Nikolova, Pangarov, Ruocco, Shield, Voineskos, Blumberger, Boileau, Bozinoff, Gerretsen, Vieira, Melamed, Sibille, Quilty and Prevot.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.

AB - Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.

KW - GABA

KW - alcohol use disorders

KW - clinical trials

KW - integrative approach

KW - interventions

KW - pharmacotherapy

KW - translational

KW - unmet need

UR - https://www.scopus.com/pages/publications/85175851599

U2 - 10.3389/fncir.2023.1218737

DO - 10.3389/fncir.2023.1218737

M3 - Review article

C2 - 37929054

AN - SCOPUS:85175851599

SN - 1662-5110

VL - 17

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

M1 - 1218737

ER -

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this