TY - JOUR
T1 - Gait impairments in Parkinson's disease
AU - Mirelman, Anat
AU - Bonato, Paolo
AU - Camicioli, Richard
AU - Ellis, Terry D.
AU - Giladi, Nir
AU - Hamilton, Jamie L.
AU - Hass, Chris J.
AU - Hausdorff, Jeffrey M.
AU - Pelosin, Elisa
AU - Almeida, Quincy J.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Gait impairments are among the most common and disabling symptoms of Parkinson's disease. Nonetheless, gait is not routinely assessed quantitatively but is described in general terms that are not sensitive to changes ensuing with disease progression. Quantifying multiple gait features (eg, speed, variability, and asymmetry) under natural and more challenging conditions (eg, dual-tasking, turning, and daily living) enhanced sensitivity of gait quantification. Studies of neural connectivity and structural network topology have provided information on the mechanisms of gait impairment. Advances in the understanding of the multifactorial origins of gait changes in patients with Parkinson's disease promoted the development of new intervention strategies, such as neurostimulation and virtual reality, aimed at alleviating gait impairments and enhancing functional mobility. For clinical applicability, it is important to establish clear links between specific gait impairments, their underlying mechanisms, and disease progression to foster the acceptance and usability of quantitative gait measures as outcomes in future disease-modifying clinical trials.
AB - Gait impairments are among the most common and disabling symptoms of Parkinson's disease. Nonetheless, gait is not routinely assessed quantitatively but is described in general terms that are not sensitive to changes ensuing with disease progression. Quantifying multiple gait features (eg, speed, variability, and asymmetry) under natural and more challenging conditions (eg, dual-tasking, turning, and daily living) enhanced sensitivity of gait quantification. Studies of neural connectivity and structural network topology have provided information on the mechanisms of gait impairment. Advances in the understanding of the multifactorial origins of gait changes in patients with Parkinson's disease promoted the development of new intervention strategies, such as neurostimulation and virtual reality, aimed at alleviating gait impairments and enhancing functional mobility. For clinical applicability, it is important to establish clear links between specific gait impairments, their underlying mechanisms, and disease progression to foster the acceptance and usability of quantitative gait measures as outcomes in future disease-modifying clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=85067007078&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(19)30044-4
DO - 10.1016/S1474-4422(19)30044-4
M3 - Review article
AN - SCOPUS:85067007078
SN - 1474-4422
VL - 18
SP - 697
EP - 708
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 7
ER -