Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich; M. Salti; S. D. Goren; E. B. Yudina; A. E. Aleksenskii; A. Ya Vul; A. I. Shames

doi:10.1021/acs.jpcc.8b11655

Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich, M. Salti, S. D. Goren, E. B. Yudina, A. E. Aleksenskii, A. Ya Vul, A. I. Shames

Department of Physics

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53 Scopus citations

Abstract

We report on the first ¹H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T₁) and spin-spin (T₂) relaxation times of water protons providing relaxivities of r₁ = 33.4 and r₂ = 332 mM^-1 s^-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

Original language	English
Pages (from-to)	2627-2631
Number of pages	5
Journal	Journal of Physical Chemistry C
Volume	123
Issue number	4
DOIs	https://doi.org/10.1021/acs.jpcc.8b11655
State	Published - 31 Jan 2019

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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title = "Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement",

abstract = "We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.",

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AU - Panich, A. M.

AU - Salti, M.

AU - Goren, S. D.

AU - Yudina, E. B.

AU - Aleksenskii, A. E.

AU - Vul, A. Ya

AU - Shames, A. I.

PY - 2019/1/31

Y1 - 2019/1/31

N2 - We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

AB - We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

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Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

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