Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich, M. Salti, S. D. Goren, E. B. Yudina, A. E. Aleksenskii, A. Ya Vul, A. I. Shames

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents. ©

Original languageEnglish
Pages (from-to)2627-2631
Number of pages5
JournalJournal of Physical Chemistry C
Volume123
Issue number4
DOIs
StatePublished - 31 Jan 2019

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy (all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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