Gene-expression studies in understanding the mechanism of action of lithium.

Lilach Toker, R. H. Belmaker, Galila Agam

    Research output: Contribution to journalReview articlepeer-review

    14 Scopus citations


    Lithium salts are among the drugs of choice for the treatment of bipolar disorder. Despite six decades of intensive research and an accumulating number of known cellular targets, lithium's mechanism of action still needs to be unraveled. The evolution of large-scale gene-expression analysis methodologies has provided a promising tool to understand the cellular events underlying the mood-stabilizing effect of the drug. However, despite great improvement achieved in transcriptome studies, findings of genes differentially expressed by lithium treatment exhibit, so far, a low reproducibility rate. This review discusses the different design and data analysis strategies applied in the studies and summarizes the possible reasons for the discrepancies among the reports.

    Original languageEnglish
    Pages (from-to)93-97
    Number of pages5
    JournalExpert Review of Neurotherapeutics
    Issue number1
    StatePublished - 1 Jan 2012

    ASJC Scopus subject areas

    • General Neuroscience
    • Clinical Neurology
    • Pharmacology (medical)


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