Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Amir Sagi, Rivka Manor, Tomer Ventura

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.

Original languageEnglish
Pages (from-to)620-645
Number of pages26
JournalGenes
Volume4
Issue number4
DOIs
StatePublished - 1 Dec 2013

Keywords

  • Androgenic gland
  • Biotechnology
  • Crustaceans
  • Gene function
  • Humoral defense mechanisms
  • Insulin-like peptide
  • RNA interference

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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