Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Amir Sagi; Rivka Manor; Tomer Ventura

doi:10.3390/genes4040620

Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Amir Sagi, Rivka Manor, Tomer Ventura

Department of Life Sciences

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.

Original language	English
Pages (from-to)	620-645
Number of pages	26
Journal	Genes
Volume	4
Issue number	4
DOIs	https://doi.org/10.3390/genes4040620
State	Published - 1 Dec 2013

Keywords

Androgenic gland
Biotechnology
Crustaceans
Gene function
Humoral defense mechanisms
Insulin-like peptide
RNA interference

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/genes4040620

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title = "Gene Silencing in Crustaceans: From Basic Research to Biotechnologies",

abstract = "Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.",

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author = "Amir Sagi and Rivka Manor and Tomer Ventura",

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AU - Ventura, Tomer

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N2 - Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.

AB - Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.

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KW - Biotechnology

KW - Crustaceans

KW - Gene function

KW - Humoral defense mechanisms

KW - Insulin-like peptide

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Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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