GeneNote: Whole genome expression profiles in normal human tissues

Orit Shmueli; Shirley Horn-Saban; Vered Chalifa-Caspi; Michael Shmoish; Ron Ophir; Hila Benjamin-Rodrig; Marilyn Safran; Eytan Domany; Doron Lancet

doi:10.1016/j.crvi.2003.09.012

GeneNote: Whole genome expression profiles in normal human tissues

Orit Shmueli, Shirley Horn-Saban, Vered Chalifa-Caspi, Michael Shmoish, Ron Ophir, Hila Benjamin-Rodrig, Marilyn Safran, Eytan Domany, Doron Lancet

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

A novel data set, GeneNote (Gene Normal Tissue Expression), was produced to portray complete gene expression profiles in healthy human tissues using the Affymetrix GeneChip HG-U95 set, which includes 62 839 probe-sets. The hybridization intensities of two replicates were processed and analyzed to yield the complete transcriptome for twelve human tissues. Abundant novel information on tissue specificity provides a baseline for past and future expression studies related to diseases. The data is posted in GeneNote (http://genecards.weizmann.ac.il/genenote/), a widely used compendium of human genes (http://bioinfo.weizmann.ac.il/genecard).

Original language	English
Pages (from-to)	1067-1072
Number of pages	6
Journal	Comptes Rendus - Biologies
Volume	326
Issue number	10-11
DOIs	https://doi.org/10.1016/j.crvi.2003.09.012
State	Published - 1 Jan 2003
Externally published	Yes

Keywords

Expression profile
GeneCards
Microarray
Normal human tissues
Transcriptome

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.1016/j.crvi.2003.09.012

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title = "GeneNote: Whole genome expression profiles in normal human tissues",

abstract = "A novel data set, GeneNote (Gene Normal Tissue Expression), was produced to portray complete gene expression profiles in healthy human tissues using the Affymetrix GeneChip HG-U95 set, which includes 62 839 probe-sets. The hybridization intensities of two replicates were processed and analyzed to yield the complete transcriptome for twelve human tissues. Abundant novel information on tissue specificity provides a baseline for past and future expression studies related to diseases. The data is posted in GeneNote (http://genecards.weizmann.ac.il/genenote/), a widely used compendium of human genes (http://bioinfo.weizmann.ac.il/genecard).",

keywords = "Expression profile, GeneCards, Microarray, Normal human tissues, Transcriptome",

author = "Orit Shmueli and Shirley Horn-Saban and Vered Chalifa-Caspi and Michael Shmoish and Ron Ophir and Hila Benjamin-Rodrig and Marilyn Safran and Eytan Domany and Doron Lancet",

note = "Funding Information: The work described in this paper was supported by the Abraham and Judith Goldwasser foundation. Doron Lancet is the incumbent of the Ralph and Lois Silver Chair in Human Genomics. Eytan Domany is the incumbent of the Henry J. Leir Professorial Chair.",

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language = "English",

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AU - Shmueli, Orit

AU - Horn-Saban, Shirley

AU - Chalifa-Caspi, Vered

AU - Shmoish, Michael

AU - Ophir, Ron

AU - Benjamin-Rodrig, Hila

AU - Safran, Marilyn

AU - Domany, Eytan

AU - Lancet, Doron

N1 - Funding Information: The work described in this paper was supported by the Abraham and Judith Goldwasser foundation. Doron Lancet is the incumbent of the Ralph and Lois Silver Chair in Human Genomics. Eytan Domany is the incumbent of the Henry J. Leir Professorial Chair.

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AB - A novel data set, GeneNote (Gene Normal Tissue Expression), was produced to portray complete gene expression profiles in healthy human tissues using the Affymetrix GeneChip HG-U95 set, which includes 62 839 probe-sets. The hybridization intensities of two replicates were processed and analyzed to yield the complete transcriptome for twelve human tissues. Abundant novel information on tissue specificity provides a baseline for past and future expression studies related to diseases. The data is posted in GeneNote (http://genecards.weizmann.ac.il/genenote/), a widely used compendium of human genes (http://bioinfo.weizmann.ac.il/genecard).

KW - Expression profile

KW - GeneCards

KW - Microarray

KW - Normal human tissues

KW - Transcriptome

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IS - 10-11

ER -

GeneNote: Whole genome expression profiles in normal human tissues

Abstract

Keywords

ASJC Scopus subject areas

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