Abstract
The Sabra salt-sensitive SBH/y and salt-resistant SBN/y rats constitute a unique experimental model of hypertension in which salt-susceptibility is genetically determined and expressed only after salt-loading, without the development of spontaneous hypertension. To determine the genetic basis of salt-susceptibility in the Sabra rats, the candidate gene and total genome screen approaches were adopted. The likely candidate genes in this model incorporate salt-related physiological mechanisms such as the nitric oxide system, the arginine vasopressin axis and the epithelial sodium channel. In the random genome search scheme for culprit genes, SBH/y and SBN/y were cross-bred. A highly unusual and composite mode of transmission of salt- susceptibility was found in this cross, emphasizing the complexity of the genetic basis of salt-susceptibility. Linkage analysis of the entire rat genome with a large number of widely distributed microsatellite markers identified three putative gene loci on chromosomes 1 and 17 that contribute importantly to salt-sensitivity and/or resistance, and uncovered sex specificity in the role that salt-susceptibility genes fulfill in the 4development of hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 1493-1500 |
| Number of pages | 8 |
| Journal | Kidney International |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Jan 1998 |
Keywords
- Arginine vasopressin
- Candidate genes
- Epithelial sodium channel
- Genome screen
- Hypertension
- Linkage analysis
- Microsatellites
- Nitric oxide
- Salt-susceptibility
- Sexual dimorphism
ASJC Scopus subject areas
- Nephrology