Genetic control of biological rhythms: Independent expression of each rhythm parameter

Leah Peleg, Alexander Zvulunov, Israel E. Ashkenazi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Biological rhythm whose pattern approaches a sinusoidal curve can be characterized by four parameters: Period, Mesor, Acrophase and Amplitude. Inheritance patterns of these parameters were assessed by monitoring White Blood Cell (WBC) count rhythms of C57BL/6J mice, BALB/c mice and the F1 progeny prior and after injection of Cisplatinum at either 0900, 1500, 2100, or 0300. All untreated mice exhibited similar WBC rhythms while a variety of rhythm phenotypes was revealed among the injected mice. Analyses of the variety in the parental strains and F1 progeny suggested that each of the rhythm parameters is independently controlled.

Original languageEnglish
Pages (from-to)1143-1149
Number of pages7
JournalLife Sciences
Volume56
Issue number13
DOIs
StatePublished - 17 Feb 1995
Externally publishedYes

Keywords

  • biological rhythms
  • chronobiology
  • genetics
  • rhythm parameters

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics

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