Genetic correlational analysis of glycogen synthase kinase-3β and prepulse inhibition in inbred mice

S. Amar, B. C. Jones, C. Nadri, N. Kozlovsky, R. H. Belmaker, G. Agam

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In humans, GSK-3β activity is diminished in schizophrenic patients as is prepulse inhibition of the startle response (PPI). We performed a genetic correlational analysis between published PPI values and frontal cortex GSK-3 activity analyzed in our laboratory in 10 inbred mouse strains. This methodology could indicate relevant parameters for study in an animal model. Indeed, we obtained significant correlations between the enzyme's activity and PPI measured by two different methods. This may indicate that investigation of the genetics of GSK-3β regulation holds promise for understanding some of the biochemical underpinnings of schizophrenia.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalGenes, Brain and Behavior
Volume3
Issue number3
DOIs
StatePublished - 1 Jun 2004

Keywords

  • Genetic correlation
  • Glycogen synthase kinase (GSK)-3
  • Inbred mice
  • Prepulse inhibition (PPI)

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