TY - JOUR
T1 - Genetic determinants of serum lipid levels in Chinese subjects
T2 - A population-based study in Shanghai, China
AU - Andreotti, Gabriella
AU - Menashe, Idan
AU - Chen, Jinbo
AU - Chang, Shih Chen
AU - Rashid, Asif
AU - Gao, Yu Tang
AU - Han, Tian Quan
AU - Sakoda, Lori C.
AU - Chanock, Stephen
AU - Rosenberg, Philip S.
AU - Hsing, Ann W.
N1 - Funding Information:
S. Chanock Core Genotyping Facility, National Cancer Institute, National Institutes of Health, Gaithersburg, MD, USA
Funding Information:
S. Chanock Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Funding Information:
Acknowledgements This research was supported by the Intramural Research Program of the NIH, National Cancer Institute; National Center on Minority Health, NIH; and Center to Reduce Cancer Disparities, NCI, NIH.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person interview. Associations between variants and mean lipid levels were examined using a test of trend and least squares mean test in a general linear model. Four SNPs were associated with lipid levels: LDLR rs1003723 was associated with total cholesterol (P-trend = 0.002) and LDL (P-trend = 0.01), LDLR rs6413503 was associated with total cholesterol (P-trend = 0.05), APOB rs1367117 was associated with apoB (P-trend = 0.02), and ABCB11 rs49550 was associated with total cholesterol (P-trend = 0.01), triglycerides (P-trend = 0.01), and apoA (P-trend = 0.01). We found statistically significant effects on lipid levels for LDLR rs6413503 among those with high dairy intake, LPL rs263 among those with high allium vegetable intake, and APOE rs440446 among those with high red meat intake. We identified new associations between SNPs and lipid levels in Chinese previously found in Caucasians. These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease.
AB - We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person interview. Associations between variants and mean lipid levels were examined using a test of trend and least squares mean test in a general linear model. Four SNPs were associated with lipid levels: LDLR rs1003723 was associated with total cholesterol (P-trend = 0.002) and LDL (P-trend = 0.01), LDLR rs6413503 was associated with total cholesterol (P-trend = 0.05), APOB rs1367117 was associated with apoB (P-trend = 0.02), and ABCB11 rs49550 was associated with total cholesterol (P-trend = 0.01), triglycerides (P-trend = 0.01), and apoA (P-trend = 0.01). We found statistically significant effects on lipid levels for LDLR rs6413503 among those with high dairy intake, LPL rs263 among those with high allium vegetable intake, and APOE rs440446 among those with high red meat intake. We identified new associations between SNPs and lipid levels in Chinese previously found in Caucasians. These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease.
KW - Chinese
KW - Serum lipid levels
KW - Single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=73449101426&partnerID=8YFLogxK
U2 - 10.1007/s10654-009-9402-3
DO - 10.1007/s10654-009-9402-3
M3 - מאמר
C2 - 19888660
AN - SCOPUS:73449101426
SN - 0393-2990
VL - 24
SP - 763
EP - 774
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 12
ER -