Genetic-environmental interactions in asthma and allergy: A study in a closed population exposed to different environments

Einat Yaari, Ziv Susser, Amnon Lahad, Yaron Nesher, Sylvia Kachalsky, Asher Tal, Eitan Kerem

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Asthma and allergy are common chronic diseases caused by genetic and environmental factors. Objective: To study the effect of different environments on the prevalence of both diseases in an isolated founder population that resettled in different geographic and environmental areas (namely, the genetically homogeneous population that immigrated to Israel from Cochin, India, 50 years ago). Methods: Respiratory and allergy symptoms were recorded by a questionnaire. The relative contribution of genetic factors on asthma and allergy was established by comparing Cochin with non-Cochin Jews living in the Jerusalem mountains; the relative contribution of the environment was determined by comparing mountain Cochin Jews with those living in the desert. The study was conducted from January to October 2004. Results: A total of 983 individuals (481 mountain Cochins, 353 desert Cochins, and 149 non-Cochins) were studied. The overall prevalence of asthma in Cochins was 23.7%; and of allergy, 29.5%. The rate of asthma and/or allergy in Cochins in the mountains was significantly higher than in control non-Cochins. The rates of both asthma and allergy among Cochin Jews in the mountains were significantly higher than those among Cochin Jews in the desert, the former because of a higher prevalence of allergic asthma. The rates of nonallergic asthma and allergy without asthma were similar in both environments. Conclusions: Two different asthma and allergy phenotypes were detected that share a distinct genetic background but differ in the environmental influences. Allergic asthma is strongly determined by both genetic and environmental factors, whereas nonallergic asthma or atopy without asthma is determined mainly by genetic factors and is less influenced by environmental factors.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Volume102
Issue number3
DOIs
StatePublished - 1 Jan 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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