Genetic linkage between X-Chromosome markers and bipolar affective illness

Miron Baron, Neil Risch, Rahel Hamburger, Batsheva Mandel, Stuart Kushner, Michael Newman, Dov Drumer, Robert H. Belmaker

Research output: Contribution to journalArticlepeer-review

325 Scopus citations


A pedigree study shows close linkage of bipolar affective illness (manic depression) to the X-chromosome markers colour blindness and glucose-6-phosphate dehydrogenase deficiency. The maximum lod score ranges from 7.52 (assuming homogeneity) to 9.17 (assuming heterogeneity); that is, the odds in favour of linkage range between 3×107 to 1 and 109 to 1. These results provide confirmation that a major psychiatric disorder can be caused by a single genetic defect. As a possible first step in characterizing the primary genetic abnormality, this finding may have important implications for the aetiology, nosology, pathophysiology and, possibly, prevention and treatment of bipolar affective disorder. It also provides a means for identifying and characterizing homogeneous populations of patients and may help in clarifying aetiological heterogeneity.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
Issue number6110
StatePublished - 1 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • General


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