Genetic relationship between dopamine transporter gene and schizophrenia: Linkage and association

W. Maier, J. Minges, N. Eckstein, C. Brodski, M. Albus, B. Lerer, J. Hallmayer, R. Fimmers, M. Ackenheil, R. E. Ebstein, M. Borrmann, D. Lichtermann, D. B. Wildenauer

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23 Scopus citations

Abstract

This study explores the genetic relationship between schizophrenia and the dopamine transporter gene (DAT) by a variety of methods. In a sample of 48 families - each family containing at least one nuclear family with a pair of affected siblings - we performed linkage analysis using the maximum likelihood (LOD score) method as well as sibpair analysis (identity by descent). In addition, we investigated a sample of 108 nuclear families - index case affected with schizophrenia/chronic schizoaffective disorder - for association using the haplotype relative risk method. Linkage between schizophrenia and DAT using two- and three-point linkage analysis was excluded with all disease models employed. No evidence for association between haplotypes of the VNTR-probe of the DAT and schizophrenia has been detected. Thus, a contribution of the DAT gene to the genetic diathesis of schizophrenia is unlikely in the families studied.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalSchizophrenia Research
Volume20
Issue number1-2
DOIs
StatePublished - 1 Jan 1996
Externally publishedYes

Keywords

  • dopamine transporter gene
  • genetic association
  • linkage
  • schizophrenia

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