TY - JOUR
T1 - Genetic variation in caspase genes and risk of non-Hodgkin lymphoma
T2 - A pooled analysis of 3 population-based case-control studies
AU - Lan, Qing
AU - Morton, Lindsay M.
AU - Armstrong, Bruce
AU - Hartge, Patricia
AU - Menashe, Idan
AU - Zheng, Tongzhang
AU - Purdue, Mark P.
AU - Cerhan, James R.
AU - Zhang, Yawei
AU - Grulich, Andrew
AU - Cozen, Wendy
AU - Yeager, Meredith
AU - Holford, Theodore R.
AU - Vajdic, Claire M.
AU - Davis, Scott
AU - Leaderer, Brian
AU - Kricker, Anne
AU - Schenk, Maryjean
AU - Zahm, Shelia H.
AU - Chatterjee, Nilanjan
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Wang, Sophia S.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) in 12 caspase and related genes in 3 population-based case-control studies (1946 cases and 1808 controls). Gene-based analysis, adjusting for the number of tagSNPs genotyped in each gene, showed significant associations for CASP8, CASP9, and CASP1. SNP-based analysis showed that CASP8 rs6736233 (odds ratio (OR) CG = 1.21; ORCC = 2.13; P trend = .011); CASP9 rs4661636 (ORCT = 0.89; ORTT = 0.77; P trend = .011); and CASP1 rs1785882 (ORAT = 1.12; ORAA = 1.30; P trend = .0054) were significantly associated with NHL risk and consistent across studies. It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis.
AB - Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) in 12 caspase and related genes in 3 population-based case-control studies (1946 cases and 1808 controls). Gene-based analysis, adjusting for the number of tagSNPs genotyped in each gene, showed significant associations for CASP8, CASP9, and CASP1. SNP-based analysis showed that CASP8 rs6736233 (odds ratio (OR) CG = 1.21; ORCC = 2.13; P trend = .011); CASP9 rs4661636 (ORCT = 0.89; ORTT = 0.77; P trend = .011); and CASP1 rs1785882 (ORAT = 1.12; ORAA = 1.30; P trend = .0054) were significantly associated with NHL risk and consistent across studies. It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis.
UR - http://www.scopus.com/inward/record.url?scp=67651089850&partnerID=8YFLogxK
U2 - 10.1182/blood-2009-01-198697
DO - 10.1182/blood-2009-01-198697
M3 - Article
C2 - 19414860
AN - SCOPUS:67651089850
SN - 0006-4971
VL - 114
SP - 264
EP - 267
JO - Blood
JF - Blood
IS - 2
ER -