Genetics of fibromyalgia

Dan Buskila; Lily Neumann

doi:10.1007/s11916-005-0005-8

Genetics of fibromyalgia

Dan Buskila, Lily Neumann

The International Center of Health Innovation & Nutrition in memory of Manya Igel

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The pathogenesis of fibromyalgia (FM) and related conditions is not entirely understood. Recent evidence suggests that these syndromes may share heritable pathophysiologic features. Familial studies suggest that genetic and familial factors may play a role in the etiopathogenesis of these conditions. There is evidence that polymorphisms of genes in the serotoninergic and catecholaminergic systems are linked to the pathophysiology of FM and related conditions and are associated with personality traits. The precise role of genetic factors in the etiopathology of FM remains unknown, but it is likely that several genes are operating together to initiate this syndrome. Larger longitudinal studies are needed to better clarify the role of genetics in the development of FM.

Original language	English
Pages (from-to)	313-315
Number of pages	3
Journal	Current Pain and Headache Reports
Volume	9
Issue number	5
DOIs	https://doi.org/10.1007/s11916-005-0005-8
State	Published - 1 Jan 2005

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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AB - The pathogenesis of fibromyalgia (FM) and related conditions is not entirely understood. Recent evidence suggests that these syndromes may share heritable pathophysiologic features. Familial studies suggest that genetic and familial factors may play a role in the etiopathogenesis of these conditions. There is evidence that polymorphisms of genes in the serotoninergic and catecholaminergic systems are linked to the pathophysiology of FM and related conditions and are associated with personality traits. The precise role of genetic factors in the etiopathology of FM remains unknown, but it is likely that several genes are operating together to initiate this syndrome. Larger longitudinal studies are needed to better clarify the role of genetics in the development of FM.

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Genetics of fibromyalgia

Abstract

ASJC Scopus subject areas

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