Genistein carbon dots exhibit antioxidant and anti-inflammatory effects in vitro

Kumar Sagar Jaiswal, Orit Malka, Nitzan Shauloff, Marina Bersudsky, Elena Voronov, Bhawna Gupta, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Genistein, an isoflavone from soybean, has attracted attention due to its health benefits, particularly antioxidant and anti-inflammatory activities. Clinical applications of genistein, however, have been limited due to the considerable hydrophobicity and lower bioavailability of the molecule. In this study, carbon dots (C-dots) synthesized from genistein as the carbonaceous precursor exhibit antioxidant properties in test-tube and cell experiments. Anti-inflammatory activity of the genistein-C-dots was also recorded in LPS stimulated macrophages, manifested in inhibition of pro-inflammatory cytokine levels and enhancement anti-inflammatory cytokine expression. The antioxidant and anti-inflammatory effects of the genistein-C-dots, particularly in comparison to the parent genistein molecules, likely account to the display of functional genistein residues on the C-dots’ surfaces, and low band gap energy facilitating electron scavenging. Importantly, the genistein-C-dots featured biocompatibility and low cytotoxicity, underlining their potential as a therapeutic vehicle against inflammatory conditions.

Original languageEnglish
Article number113173
JournalColloids and Surfaces B: Biointerfaces
StatePublished - Mar 2023


  • Anti-inflammation
  • Antioxidants
  • Carbon dots
  • Genistein
  • Isoflavone
  • Phytochemicals

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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