Genomic Research in Rat Models of Kidney Disease

Yoram Yagil, Ronen Levi-Varadi, Chana Yagil

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Current understanding of the mechanisms underlying renal disease in humans is incomplete. Consequently, our ability to prevent the occurrence of renal disease or treat established kidney disease is limited. Investigating kidney disease directly in humans poses objective difficulties, which has led investigators to seek experimental animal models that simulate renal disease in humans. Animal models have thus become a tool of major importance in the study of renal physiology and have been crucial in shedding light on the complex mechanisms involved in kidney function and in our current understanding of the pathophysiology of renal disease. Among animal models, the rat has been the preferred and most commonly used species for the investigation of renal disease. This chapter reviews what has been achieved over the years, using the rat as a tool for the investigation of renal disease in humans, focusing on the contribution of rat genetics and genomics to the elucidation of the mechanisms underlying the pathophysiology of the major types of renal disease, including primary and secondary renal diseases.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages287-307
Number of pages21
DOIs
StatePublished - 1 Jan 2019

Publication series

NameMethods in Molecular Biology
Volume2018
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Disease
  • Experimental models
  • Expression
  • Function
  • Genes
  • Genetic basis
  • Genomics
  • Kidneys
  • Mechanisms
  • Pathophysiology
  • Primary kidney disease
  • Proteomics
  • Rat
  • Rodents
  • Secondary kidney disease
  • Transcriptomics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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