TY - JOUR
T1 - Genomically recoded organisms
T2 - redefining and safeguarding biological systems
AU - Amiram, Miriam
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/1/1
Y1 - 2025/1/1
N2 - In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.
AB - In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.
KW - biocontainment
KW - genomically recoded organisms
KW - noncanonical amino acids
KW - orthogonal translation machinery
UR - http://www.scopus.com/inward/record.url?scp=105001873753&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2025.03.014
DO - 10.1016/j.tibtech.2025.03.014
M3 - Short survey
C2 - 40185668
AN - SCOPUS:105001873753
SN - 0167-7799
JO - Trends in Biotechnology
JF - Trends in Biotechnology
ER -