GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis

David Shaki, Eli Hershkovitz, Shai Tamam, Arkadi Bollotin, Odeya David, Guy Yalovitsky, Neta Loewenthal, Lior Carmon, Dganit Walker, Alon Haim

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations


    Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Design: Systematic review and mini meta-analysis of the literature. Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. Results: In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. Conclusions: A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.

    Original languageEnglish
    Article number1132296
    JournalFrontiers in Pediatrics
    StatePublished - 1 Jan 2023


    • Down syndrome
    • IGF1
    • bio-inactive GH
    • growth hormone
    • hypothalamus
    • neurosecretory dysfunction

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health


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