GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis

David Shaki; Eli Hershkovitz; Shai Tamam; Arkadi Bollotin; Odeya David; Guy Yalovitsky; Neta Loewenthal; Lior Carmon; Dganit Walker; Alon Haim

doi:10.3389/fped.2023.1132296

GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis

David Shaki, Eli Hershkovitz, Shai Tamam, Arkadi Bollotin, Odeya David, Guy Yalovitsky, Neta Loewenthal, Lior Carmon, Dganit Walker, Alon Haim

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2 Scopus citations

Abstract

Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Design: Systematic review and mini meta-analysis of the literature. Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. Results: In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. Conclusions: A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.

Original language	English
Article number	1132296
Journal	Frontiers in Pediatrics
Volume	11
DOIs	https://doi.org/10.3389/fped.2023.1132296
State	Published - 21 Feb 2023

Keywords

Down syndrome
IGF1
bio-inactive GH
growth hormone
hypothalamus
neurosecretory dysfunction

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.3389/fped.2023.1132296

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title = "GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis",

abstract = "Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Design: Systematic review and mini meta-analysis of the literature. Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. Results: In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. Conclusions: A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.",

keywords = "Down syndrome, IGF1, bio-inactive GH, growth hormone, hypothalamus, neurosecretory dysfunction",

author = "David Shaki and Eli Hershkovitz and Shai Tamam and Arkadi Bollotin and Odeya David and Guy Yalovitsky and Neta Loewenthal and Lior Carmon and Dganit Walker and Alon Haim",

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doi = "10.3389/fped.2023.1132296",

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T2 - A systematic review and mini meta-analysis

AU - Shaki, David

AU - Hershkovitz, Eli

AU - Tamam, Shai

AU - Bollotin, Arkadi

AU - David, Odeya

AU - Yalovitsky, Guy

AU - Loewenthal, Neta

AU - Carmon, Lior

AU - Walker, Dganit

AU - Haim, Alon

N1 - Publisher Copyright: 2023 Shaki, Hershkovitz, Tamam, Bollotin, David, Yalovitsky, Loewenthal, Carmon, Walker and Haim.

PY - 2023/2/21

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N2 - Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Design: Systematic review and mini meta-analysis of the literature. Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. Results: In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. Conclusions: A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.

AB - Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Design: Systematic review and mini meta-analysis of the literature. Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. Results: In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. Conclusions: A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.

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GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis

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Keywords

ASJC Scopus subject areas

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