GLADOVANJE MOŽE PROMIJENITI NASLJEĐIVANJE DUŽINE TELOMERA PO OČEVOJ, ALI NE I PO MAJČINOJ LINIJI KROZ GENERACIJE: RETROSPEKTIVNA KOHORTNA STUDIJA

Translated title of the contribution: Starvation May Change the Type of Paternal but Not Maternal Inheritance of the Telomere Length Throughout Generations: A Retrospective Cohort Study

Leonid Kalichman, Anna M. Chumakova, Arcady Torchinsky, Eugene Kobyliansky

Research output: Contribution to journalArticlepeer-review

Abstract

Our aim was to evaluate the effect of starvation on the paternal and maternal inheritance of the leucocyte telomere length (LTL) in three birth cohorts: before, during, and after the Chuvashian famine of 1922–1923. This retrospective cohort study comprised native Chuvash men (n= 678) and women (n=647) born between 1909–1980. Data were gathered during three expeditions: 1994, 1999, 2002, enabling us to treat age and birth year as independent variables. LTL was measured by a quantitative polymerase chain reaction technique. A significant difference in LTL values (χ2 d.f=2=79.04, p<0.0001) was observed between the sexes. In a pedigree-based variance component analysis, ~67.4% of the LTL variation was explained by an additive genetic component. In the entire sample, a significant correlation was observed between the LTL of the parents and offsprings. Fathers born between 1924–1928 demonstrated a significantly stronger LTL correlation with their offsprings. The LTL correlation between mothers and offspring in this group and between parents and offspring in those born after 1928 did not differ from the entire population. We believe that the increased correlation between the LTL in the father-offspring pairs born after starvation in Chuvashia can be explained by differences in the processes of oogenesis and spermatogenesis in humans.

Translated title of the contributionStarvation May Change the Type of Paternal but Not Maternal Inheritance of the Telomere Length Throughout Generations: A Retrospective Cohort Study
Original languageCroatian
Pages (from-to)1-7
Number of pages7
JournalCollegium Antropologicum
Volume46
Issue number1
DOIs
StatePublished - 1 Jan 2022

Keywords

  • cohort study
  • famine
  • inheritance
  • starvation
  • telomeres

ASJC Scopus subject areas

  • Anthropology
  • Arts and Humanities (miscellaneous)

Fingerprint

Dive into the research topics of 'Starvation May Change the Type of Paternal but Not Maternal Inheritance of the Telomere Length Throughout Generations: A Retrospective Cohort Study'. Together they form a unique fingerprint.

Cite this