Global longitudinal strain and long-term outcome in patients presenting to the emergency department with suspected acute coronary syndrome

Alexander Fuks, Noah Liel-Cohen, David S. Blondheim, Sara Shimoni, Mohamed Jabaren, Marina Leitman, Salim Adawi, Ronen Jaffe, Basheer Karkabi, Ihab Asmer, Majdi Ganaeem, Sergio L. Kobal, Idit Lavi, Walid Saliba, Avinoam Shiran

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: We have previously shown that 2-dimentional strain is not a useful tool for ruling out acute coronary syndrome (ACS) in the emergency department (ED). The aim of the present study was to determine whether in patients with suspected ACS, global longitudinal strain (GLS), measured in the ED using 2-dimensional strain imaging, can predict long-term outcome. Methods: Long-term (median 7.7 years [IQR 6.7–8.2]) major adverse cardiac events (MACE; cardiac death, ACS, revascularization, hospitalization for heart failure, or atrial fibrillation) and all-cause mortality data were available in 525/605 patients (87%) enrolled in the Two-Dimensional Strain for Diagnosing Chest Pain in the Emergency Room (2DSPER) study. The study prospectively enrolled patients presenting to the ED with chest pain and suspected ACS but without a diagnostic ECG or elevated troponin. GLS was computed using echocardiograms performed within 24 hours of chest pain. MACE of patients with worse GLS (>median GLS) were compared to patients with better GLS (≤ median GLS). Results: Median GLS was −18.7%. MACE occurred in 47/261 (18%) of patients with worse GLS as compared with 45/264 (17%) with better GLS, adjusted HR 0.87 (95% CI 0.57–1.33, P =.57). There was no significant difference in all-cause mortality or individual endpoints between groups. GLS did not predict MACE even in patients with optimal 2-dimensional image quality (n = 164, adjusted HR=1.51, 95% CI 0.76–3.0). Conclusions: Global longitudinal strain did not predict long-term outcome in patients presenting to the ED with chest pain and suspected ACS, supporting our findings in the 2DSPER study.

Original languageEnglish
Pages (from-to)1254-1262
Number of pages9
JournalEchocardiography
Volume38
Issue number8
DOIs
StatePublished - 1 Aug 2021

Keywords

  • acute coronary syndrome
  • global longitudinal strain
  • long-term outcome
  • major adverse cardiac events
  • speckle tracking echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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