Glucocorticoid receptor expression in breast cancer associates with older patient age

Larissa Belova; Bertha Delgado; Masha Kocherginsky; Amal Melhem; Olufunmilayo I. Olopade; Suzanne D. Conzen

doi:10.1007/s10549-008-0136-9

Glucocorticoid receptor expression in breast cancer associates with older patient age

Larissa Belova
, Bertha Delgado
, Masha Kocherginsky
, Amal Melhem
, Olufunmilayo I. Olopade
, Suzanne D. Conzen

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Breast Cancer Research and Treatment
Volume	116
Issue number	3
DOIs	https://doi.org/10.1007/s10549-008-0136-9
State	Published - 1 Aug 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Keywords

Estrogen receptor
Glucocorticoid receptor
HER2
Health disparities
Progesterone receptor
Triple-negative disease

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1007/s10549-008-0136-9

Cite this

@article{e0a6a6c470e54973b9b8f6c244e0a149,

title = "Glucocorticoid receptor expression in breast cancer associates with older patient age",

abstract = "Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.",

keywords = "Estrogen receptor, Glucocorticoid receptor, HER2, Health disparities, Progesterone receptor, Triple-negative disease",

author = "Larissa Belova and Bertha Delgado and Masha Kocherginsky and Amal Melhem and Olopade, \{Olufunmilayo I.\} and Conzen, \{Suzanne D.\}",

year = "2009",

month = aug,

day = "1",

doi = "10.1007/s10549-008-0136-9",

language = "English",

volume = "116",

pages = "441--447",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Glucocorticoid receptor expression in breast cancer associates with older patient age

AU - Belova, Larissa

AU - Delgado, Bertha

AU - Kocherginsky, Masha

AU - Melhem, Amal

AU - Olopade, Olufunmilayo I.

AU - Conzen, Suzanne D.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.

AB - Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.

KW - Estrogen receptor

KW - Glucocorticoid receptor

KW - HER2

KW - Health disparities

KW - Progesterone receptor

KW - Triple-negative disease

UR - https://www.scopus.com/pages/publications/70349570432

U2 - 10.1007/s10549-008-0136-9

DO - 10.1007/s10549-008-0136-9

M3 - Article

C2 - 18668364

AN - SCOPUS:70349570432

SN - 0167-6806

VL - 116

SP - 441

EP - 447

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Glucocorticoid receptor expression in breast cancer associates with older patient age

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this