Glucose Oxidase Patterned Meta-Chemical Surface for Sensing Glucose Using Dip-Pen Nanolithography

Numerous studies have been done to advance the development of efficient, simple, and cheap sensors, especially for glucose, which are important in the pharmaceutical and food industries. The most common sensors and biosensors used today are based on electrochemistry. The novelty of this study is the use of dip-pen nanolithography (DPN) in order to pattern a mixture of glucose oxidase with PMMA as nanoclusters and develop meta-chemical surface (MCS), which leads to highly efficient working electrodes with increased detection sensitivity compared to the today-known glucose sensors ((Formula presented.) M was detected in the current study). Our novel and important results support the feasibility of using DPN to develop sensors on various electrode surfaces patterned with different active species, especially in systems requiring target substance detection over large concentration ranges.