Glucose responsive hydrogels for medical applications

Joseph Kost, M. Goldraich

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In order to develop glucose sensitive insulin delivery systems, several researchers proposed reservoir systems consist of immobilized glucose oxidase in a pH responsive polymeric hydrogel, enclosing a saturated insulin solution. The objective of this study was to evaluate a matrix system in which the drug and the enzyme are uniformly distributed, throughout a solid polymer. Hydrogels with immobilized glucose oxidase display faster and higher swelling and release rates at higher glucose concentrations. Similar results were obtained for bacitracin release. The release rates increase when the pH step is from the higher value to the lower and decrease when the change is in the opposite direction.

Original languageEnglish
Title of host publicationPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
PublisherPubl by ACS
Pages228-229
Number of pages2
ISBN (Print)0841222169
StatePublished - 1 Dec 1992
Externally publishedYes

Publication series

NamePolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume66
ISSN (Print)0743-0515

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